Sr. Analytical Scientist

Job Description

Job Summary:

• The Senior Scientist will join the Analytical R&D Department at our Life Sciences R&D facility in St. Louis.
• In this role, you will be part of an active, multidisciplinary group of scientists dedicated to providing high level analytical
• support to product development scientists in R&D, manufacturing groups, and special project teams.
• You will be expected to lead development of LC-MS assays for the quantitation of proteins in complex mixtures.
• Additionally, you will perform advanced characterization of large biomolecules including monoclonal antibodies, multispecifics, and antibody drug conjugates.

Required Qualifications:

• BS in Chemistry or related field.
• Demonstrated hands-on proficiency with advanced instrumentation, such as with high resolution and triple quadrupole LC-MS platforms.
• Expertise with a variety of enzymatic and chemical methods of sample preparation for large biomolecule LC-MS, such as digestion, enrichment, depletion, and labelling.
• The ability to work and communicate effectively both independently and in a team-oriented environment.

Preferred Qualifications:

• PhD in Analytical Chemistry or related field.
• Expertise in absolute quantitation of proteins and antibodies by Multiple Reaction Monitoring (MRM) and/or Parallel Reaction Monitoring (PRM) mass spectrometry.
• Expertise in bottom up, middle up/down, and top down protein LC-MS workflows.
• Experience with specific workflows such as non-reduced and reduced intact mass analysis, pepProduct mapping, disulfide mapping, Post-Translational Modifications (PTM) characterization, glycosylation profiling, and free thiol analysis.
• Expertise with bioinformatics related to the quantitation and characterization of large biomolecules such as UNIFI, BioPharma Finder, Mascot, and Scaffold.
• Ideal candidate would have proficiency in a variety of instrument platforms such as Thermo, Sciex, Waters, and Agilent mass spectrometers.
• In addition to Client-MS techniques the ideal candidate would also have hands-on experience with MALDI-MS.

Must have:

• Experience: if they have a PhD, they can be flexible on having industry experience.
• Mass Spectrometry experience.
• 80% lab based.
• Independent worker.
• Local candidates.