Senior Scientist – III

Job Description

Job Summary:

• The Neuroscience Department is seeking a highly motivated contractor to support the design, execution, and advancement of preclinical pain pharmacology studies.
• The successful candidate will play a key role in expanding the team’s in vivo capabilities through the establishment and execution of mouse pain models while supporting ongoing rat behavioral pharmacology studies across multiple discovery-stage programs.
• This position will contribute directly to mechanism-of-action, PK-PD, and translational pharmacology studies supporting pain Clients.
• The individual will work closely with scientists across biology, pharmacology, DMPK, chemistry, and translational sciences to generate high-quality data that informs project decisions.

Primary Responsibilities:

• Establish, optimize, and execute mouse pain models and associated behavioral endpoints to support discovery and translational research programs.
• Perform surgical procedures required for rodent pain models.
• Conduct behavioral assessments including: Von Frey mechanical sensitivity testing, Static weight-bearing (SWB) assessments.
• Additional pain-related behavioral endpoints as needed.
• Support pharmacology studies evaluating mechanism of action, Client engagement, and PK-PD relationships.
• Assist with development and implementation of biomarker-enabled studies to support ROP and translational objectives.
• Perform rodent dosing, sample collection, and study monitoring activities.
• Maintain detailed study records and ensure accurate and timely data reporting.
• Analyze, interpret, and communicate experimental results to multidisciplinary project teams, as needed.
• Assist with study planning, protocol development, and assay optimization activities.
• Support expansion of internal in vivo capabilities while working collaboratively with external CRO partners.

Required Qualifications:

• Bachelor’s degree with 8 years or Master’s degree with 5years and PHD with 2years in Neuroscience, Pharmacology, Biology, Physiology, or a related scientific discipline.
• Hands-on experience conducting rodent behavior pharmacology studies.
• Demonstrated experience with mouse pain models and related surgical procedures.
• Experience with rodent handling, dosing(nice to have), tissue collection(nice to have) and study execution(important).
• Strong organizational skills, attention to detail, and ability to work independently.
• Excellent written and verbal communication skills.
• Ability to work effectively in a collaborative, fast-paced drug discovery environment.

Preferred Qualifications:

• Experience with osteoarthritis, inflammatory pain, neuropathic pain, and/or neuroinflammation models.
• Knowledge of PK-PD study design and interpretation.
• Experience with biomarker collection and analysis.
• Familiarity with electronic data capture and statistical analysis software.
• Experience supporting antibody and small molecule discovery programs.
• Interest in learning and supporting in vivo electrophysiology studies.