Bench Scientist – II

Job Description

Job Summary:

• The group supports non-GMP transient protein lead production across Client’s diverse biotherapeutic discovery portfolio to enable Client’s research units and their pre-clinical therapeutic in-vitro and in-vivo needs.
• The BEP DNA production and protein expression group is looking for a laboratory technician to provide DNA production support for the protein expression and purification activities in BEP.
• The candidate is expected to have a strong background in molecular biology techniques and experience with nucleic acid production and analysis.
• The successful candidate will grow bacterial cultures and perform large-scale DNA production activities following standardized protocols.
• The candidate will be a key contributor to the scientific team responsible for protein expression and purification.

Duties and Responsibilities:

• Independently execute high-throughput plasmid DNA production workflows including bacterial culture, plasmid purification, and downstream sample handling.
• Operate and troubleshoot automated instrumentation including Biotage, Opentrons, and related liquid handling platforms.
• Perform DNA quality control testing including gel electrophoresis, nucleic acid quantification, purity assessment, and endotoxin testing.
• Prepare and submit samples for next-generation sequencing (NGS) and support basic data review of sequencing results.
• Manage plasmid DNA inventory, sample storage, and tracking within electronic databases and sample management systems.
• Maintain accurate records in an electronic lab notebook and ensure documentation compliance.
• Collaborate with expression and purification scientists to ensure timely DNA delivery for downstream workflows.
• Contribute to process improvements to enhance throughput, reproducibility, and cycle time.
• Communicate progress, priorities, and risks to meet production schedules and deadlines.

Education

• B.S. in Biological Sciences, Molecular Biology, Biotechnology, Biochemistry, or a related life sciences discipline.

Required qualifications:

• 2+ years experience with molecular biology techniques including plasmid preparation, nucleic acid. purification, and quantitative DNA analysis.
• 2+ years experience with bacterial cell culture systems.
• Proficiency in DNA QC methods including gel electrophoresis and sample preparation for sequencing.
• Experience operating automated or semi-automated lab instrumentation.
• Strong organizational skills with the ability to manage multiple projects in a high-throughput setting.
• Proficiency with electronic lab notebooks and sample tracking systems.
• Attention to detail during repetitive, high-volume tasks.
• Strong communication and teamwork skills.
• Commitment to laboratory safety and compliance.

Preferred Qualifications:

• Experience with NGS library preparation or sequencing workflows.
• Familiarity with Python scripting for data analysis or workflow automation.
• Experience with plate-based (96/384-well) high-throughput workflows.
• Familiarity with LIMS or sample management platforms (e.g., FreezerPro, Genedata).