Scientist I

Job Description

Job Summary:

• We are seeking a highly motivated and skilled Scientist to join our Biochemical and Cellular Pharmacology Department.
• This hands-on, laboratory-based role focuses on the development and execution of induced proximity-based assays crucial for the discovery and validation of Client therapeutic compounds.
• The successful candidate will work at the heart of a multi-disciplinary environment, translating experimental data into actionable insights for our drug discovery programs.
• In this role, the candidate will have the unique opportunity to pioneer new induced-proximity approaches and help shape the scientific direction of early-stage drug-discovery programs.

Duties and Responsibilities:

• Assay Development: Design and develop biochemical and cell-based assays for quantitative measurement of protein–protein and protein–small molecule interactions.
• Screening & Validation: Conduct routine screening and deep-dive validation studies to support lead identification and optimization.
• Data Analysis: Perform rigorous analysis of complex data sets, ensuring high quality and reproducibility.
• Cross-Functional Collaboration: Partner effectively with colleagues in Pharmacology, Protein Science, Medicinal Chemistry and Research Biology.
• Communication: Prepare technical reports and present findings clearly during multi-disciplinary project team meetings.

Education & Experience:

• Degree: B.S. or M.S. in Biochemistry, Biophysics, Cellular/Molecular Biology, or a related scientific discipline.
• 1–3 years of hands-on laboratory experience within an academic, biotechnology, or pharmaceutical industry setting.

Mandatory Skills Requirements:

• Demonstrated experience designing, developing, validating, and executing cellular and biochemical assays, supported by a strong theoretical and practical understanding of biochemistry and biophysics relevant to complex protein systems.
• Direct experience with induced proximity assays and modalities (molecular glues, bivalent degraders, ternary complexes and multicomponent binding systems).
• Proficiency with data analysis methods and specialized software.
• Ability to move beyond default vendor fits and analyze complex system behavior using Prism, Python, R or comparable tools.
• Proven ability to critically analyze and interpret complex data sets, troubleshoot experimental hurdles, and a proactive interest in adopting new technologies.

Preferred Technical Skills (Advantageous):

• Experience with protein biochemistry, recombinant protein expression and molecular biology methods (e.g. western blot, cell culture, cell growth assays).
• Experience with nanoBRET, nanoBiT, TR-FRET, BRET as well as imaging-based approaches.
• Familiarity with automated or semi-automated laboratory instrumentation (e.g., liquid handlers, plate washers).
• Ability to thrive in a fast-paced, dynamic environment and remain productive through shifting priorities or project changes.
• Proven ability to work effectively as part of a high-functioning, multi-disciplinary team.
• A proactive approach to troubleshooting and a keen interest in learning new technologies as project needs evolve.