Principal Scientist

Job Description

Job Summary:

• We are responsible for inventing, characterizing, and advancing Client genetic therapeutics for a myriad of clinical applications.
• Our team works cross-functionally within our organization across multiple platform technologies and disease areas.
• This role may require up to 10% travel for conferences or training.

Duties and Responsibilities:

• Work with team members to drive forward new gene therapy programs
• Perform cell culture and molecular biology experiments and establish new functional assays to measure gene therapy outcomes both in vitro and in vivo.
• Establish and characterize Client assays for endpoint analysis to in vivo studies
• Work cross functionally to deliver data to the project team within expected timelines.
• Maintain detailed documentation of scientific work in an electronic notebook.

Education & Experience:

• B.S. and/or M.S. in biology or a closely related field with 3+ years of relevant laboratory experience

Additional Skills/Preferences:

• Significant aseptic cell culture experience, including gene therapy (e.g. AAV or LNP) experiments.
• Experience isolating nucleic acids and proteins from tissues.
• Experience planning and implementing experiments independently.
• Experience in molecular endpoints, including, PCR, qPCR, ddPCR, and protein analysis (Simple Western Jess, ELISA, MSD, Octet).
• Familiarity with primer design, sequencing preparation, and analysis.
• Mouse and NHP Tissue processing is a plus.
• Experience using automation in workflows is a plus (i.e., liquid handling).
• Excellent problem-solving skills and ability to troubleshoot complex issues.
• Strong organization, communication, and collaboration skills.