Bench Scientist II

Job Description

Job Summary:

• As a Scientist (non-PhD) on our Client Biology team, you will be a key driver in advancing next-generation Client technologies through collaborative, cross-functional research that spans from early discovery to pre-clinical development.
• You will develop assays and execute screening and identification of Client chemotypes that function as payloads for antibody drug conjugates for cancer therapy.
• You will work collaboratively with chemistry and other cross functional teams to understand mechanism of action of identified payloads.
• You will analyze, interpret and communicate the data effectively to key stake holders.

Duties and Responsibilities:

• Apply cellular, biochemical, immunological, and molecular biology laboratory techniques to preclinical research projects in the areas of Cancer signaling and Cancer biology.
• Investigate MOAs of our therapeutics through development, optimization, and execution of complex assays.
• Interact and collaborate with other functional groups across research.
• Provide leadership within technical area of expertise; may train, direct or mentor others.
• Design and execute key experiments to investigate Client therapeutic targets and MOAs of Client payloads to enable clear go/no-go decisions.
• Independently analyze data, document results, and present findings to large and small audiences.
• Maintain rigorous records of experimental progress using electronic laboratory notebooks.
• Present experimental results and scientific rationale to colleagues.
• Execute molecular, biochemical and cell-based methodologies including cytotoxicity assays, HiBit, HTRF, ELISA, western blotting, automated liquid handling multicolor flow cytometry, immunofluorescence and live cell microscopy.
• Aid in execution and analysis of additional experiments as need arises within the Client discovery research team.

Education and Experience:

• Bachelor’s degree in Cellular or Molecular Biology, Immunology, Biochemistry or related field and 6+ years’ relevant industry experience OR.
• M.S. degree in Cellular or Molecular Biology, Immunology, Biochemistry or related field with 4+ years’ relevant industry experience.
• Experience with Microsoft Office (Excel, Word, PowerPoint) and analytical (Prism, FlowJo, etc.) software programs.
• Experience designing, performing and interpreting complex experiments that require significant insight into problems being addressed with some guidance.
• Experience in experimental cancer biology, biochemical and/or immunological techniques (e.g., Cell culture, cytotoxicity assays, HiBit, HTRF, ELISA, western blotting, automated liquid handling multicolor flow cytometry, immunofluorescent and live cell microscopy.).
• Experience working independently and working on multiple projects.
• Experience collaborating across teams and a variety of disciplines to provide experimental expertise and support others on joint projects.
• Experience leading parts of projects or initiatives within area of expertise.
• Excellent written/oral communication skills with experience presenting/sharing details of the work with key stake holders.
• Experience developing complex cell and biochemical assays.

Preferred Knowledge:

• Working knowledge in specific areas of Cancer Biology and Cancer therapeutics esp, small molecule agents, Biologics and ADCs.
• Background knowledge of the field of cell signaling and biochemistry.