Lab Technical Operations Specialist

Job Description

Job Summary:

• We are looking for a motivated Lab Technical Operations Specialist to join our Manufacturing Science and Technology (MSAT) team. This role is critical for advancing our CAR-T and PSC process development and requires expertise in cell culture and strong data management skills.

Duties and Responsibilities:

The primary focus of this role involves hands-on laboratory work and meticulous data management.

CAR-T Cell Processing:

• Execute the ADA CAR-T process on donor materials, requiring proven experience in laboratory cell culture techniques.
• Support process improvement and characterization studies for allogeneic CAR-T processes.

Pluripotent Stem Cell Processing (PSC):

• Culture, maintain, and differentiate PSCs, specifically hESCs.
• Culture Retinal Pigmented Epithelial (RPE) cells, in both 2D tissue culture flasks and 3D stirred tank bioreactors.
• Support process improvement and characterization studies for PSC and RPE processes.

Documentation and Data Management:

• Thoroughly document experiments in the Benchling electronic laboratory notebook (ELN), adhering strictly to Good Documentation Practices (GDP).
• Perform review and approval of completed experiments within the Benchling ELN.
• Manage in-process and analytical data by accurately transcribing data from various sources into a central data tool.
• Verify data accuracy during transcription and perform process monitoring to identify potential trends.
• Assist with analyzing data and preparation of experimental protocols, reports, and presentations.

Logistics and Coordination:

• Manage process materials and inventory by collaborating with procurement, warehouse, and Vendor Managed Inventory (VMI) personnel.
• Maintain appropriate material stock levels.
• Coordinate the shipping of laboratory samples to various internal and external teams across the network and third-party testing partners.

Requirements:

• HM ok with graduate level experience.
• Must have cell culture experience.
• Experience in laboratory cell culture is required for execution of the CAR-T, PSC, and RPE process.
• Demonstrated proficiency with electronic laboratory notebooks (ELNs), preferably Benchling.
• Strong understanding of Good Documentation Practices (GDP).
• Excellent data entry and data verification skills, with an eye for detail and trend identification.
• Experience or comfort collaborating with cross-functional teams (e.g., procurement, logistics).
• Ability to manage complex logistics, including sample coordination and shipping.