Research Scientist II

Job Description

Job Summary:

• It is highly desired that you will have experience in applying diverse mass spectrometric workflows such as high-resolution and triple quadrupole mass spectrometry to characterize and quantify drug and its metabolites via in vitro and in vivo assays.
• Experience in the bioanalysis and quantitation of pharmaceuticals in biological matrices and familiarity with oligonucleotide Product bioanalysis would be a major advantage.
• Reports to Director, Bioanalytical Chemistry.

Responsibilities:

• Develop advanced and robust LC-MS analytical methods for the bioanalysis of different molecular formats such as small molecules, oligonucleotide Products, pep Products, and/or proteins.
• Develop and implement innovative high-resolution mass spectrometry-based metabolite profiling and identification platforms.
• Perform LC-MS-based small molecule biomarker analysis occasionally.
• Review and translate complex LC-MS-based data sets and articulate findings to project teams.
• Maintain/document records of all experiments, including QC review data, experimental results, and reports as appropriate into electronic laboratory notebooks.
• Contribute to the team’s knowledge through updating scientific literature and discussions.
• Maintain and troubleshoot lab instruments such as biological sample extraction systems, HPLC, and LC-MS.

Physical Requirements:

• Approximately 0-10% overnight travel.
• Ability to lift 0-10 lbs.

Qualifications Required:

• PhD or Master’s degree in pharmaceutical sciences, analytical chemistry, chemistry, biochemistry or related disciplines with relevant experience from industry or academia required.
• 3-5 years of relevant experience with a PHD or 5+ years of relevant experience with a Master.
• Demonstrable superior laboratory skills in biological sample extraction, chromatography, and/or quantitative/qualitative Mass Spectrometry.
• Experience with bioanalysis of different molecular formats such as small molecules, pep Products, oligonucleotide Products and/or proteins.
• Self-motivated with a proactive mindset.
• Excellent communication skills (both written and oral).
• Ability to thrive in a multi-disciplinary and fast-paced research environment with tight deadlines.

Qualifications Preferred:

• Experience with LC-MS-based ADME and/or bioanalytical assays.
• Experience with Analyst TM, Xcalibur TM, MassLynx TM and/or other Mass Spectrometry data-acquisition software packages.
• Experience with Graph Pad Prism, WinNonlin, Promass, or Biopharma Finder.
• Knowledge of guidance for industry bioanalytical method validation.