Associate Scientist

Job Description

Job Summary:

• The primary focus of this Associate Scientist will be to support downstream process development and characterization of early and late-stage viral vectors (lentiviral vectors and/or adeno-associated viruses).
• This position will be providing technical subject matter expertise with internal and/or external development and manufacturing collaborators for activities including tech transfer, process characterization, and pre-clinical or clinical process lifecycle management.

Duties and Responsibilities:

• Design, execute, and troubleshoot downstream development experiments supporting next-generation lentiviral vector production.
• Identify, onboard, and develop Client downstream technologies in collaboration with internal and external partners.
• Provide experimental design and executional support to team members.
• Support cross-functional development efforts e.g. downstream process development, high-throughput process development.
• Perform hands-on experimental work in the early-phase development and optimization of primarily downstream (clarification, chromatography, tangential and normal flow filtration) unit operations for viral vector production.
• Work independently and within teams to design, execute, and analyze experiments.
• Maintain accurate and detailed laboratory notebook and documentation.
• Summarize and present data in group meetings and contribute to group discussions and team strategy.
• Author technical reports and study memos.

Education and Experience:

• B.S. with 2+ years of experience or M.S. with 0-2 years of hands-on downstream experience.
• Experience with Akta Avant chromatography systems and Unicorn software.
• Experience with automated and semi-automated filtration systems (Pendotech, Repligen KR2i, Ambr Crossflow, etc).
• Hands-on process development experience.
• Degree in biological or chemical engineering, biochemistry, or bio-related field.
• Experience in the development of viral vectors (e.g. adeno-, retro-, lenti-), including successful transfer for GMP manufacturing.
• Experience with single-use technologies.

Knowledge, Skills and Abilities:

• Independently motivated with ability to multi-task, problem-solve, and coordinate activities within a team
• Ability to design experiments with design of experiment (DOE) approaches, perform experiments, and interpret the results using statistical software (ex. JMP).

Additional Job Requirements:

• Position Handles Hazardous Materials.