Senior Associate Scientist I

Job Description

Duties and Responsibilities:

• Hands-on lab support and process development for the chemical synthesis and downstream processing of OligonucleoProduct-based drug substance.
• Synthesis of OligonucleoProduct up to 11 mmol scale.
• Downstream processing of OligonucleoProduct including prep-HPLC, Ultrafiltration, annealing, concentration and Lyophilization.
• In process analytical testing including AX-HPLC, IPRP-HPLC, LCMS, UV-vis.
• Technical support for optimization of contract manufacturing processes.

Education and Experience:

• BS in Chemistry with 3+ years lab experience, preferably in an industrial setting.
• Basic understanding of analytical techniques (pH, osmolality, conductivity measurement, HPLC, LC-MS etc.).
• Related hands-on experience is preferred.
• Experience in record-keeping and excellent laboratory documentation practice, are required.

Knowledge, Skills and Abilities:

• Knowledge of OligonucleoProduct manufacture process including phosphonamidite chemistry, chromatography, ultrafiltration etc. is a plus.
• Strong commitment to high laboratory and scientific standard; ability to maintain a safe, clean, and orderly laboratory work environment; assist in routine lab and equipment maintenance.
• Good communication skills are a must for this position.
• The successful candidate must be a responsible and proactive individual who is able to work as a team player in a highly dynamic environment with aggressive timelines.
• OligonucleoProduct synthesis and downstream processing, Analytical HPLC/LCMS/UV-vis