Scientist I

Job Description

Job Summary:

• We are looking for a highly motivated scientist to join our structural biology and biophysics group at Client in Cambridge MA.
• As a key member of our dynamic team, you will be responsible for determining critical structural biology data through both cryo-electron microscopy and x-ray crystallography; actively pursuing solutions for unmet medical needs in diverse therapeutic areas and collaborating with multidisciplinary teams within Client.
• The successful candidate will excel in a fast-paced, highly diverse discovery environment, will have a strong focus on scientific rigor, have proven success in organized and independent work, and an exceptional attention to detail.
• Applicants who are passionate about structural biology are encouraged to apply.

Responsibilities and Duties:

• Determine structural biology data using cryo-electron microscopy (Cryo-EM) and X-ray crystallography.
• Analyze molecular interactions and propose structure-based optimizations to support small-molecule drug discovery.
• Provide scientific expertise to project teams working on different drug modalities.

Design and conduct experiments independently for structure determination, including:

• Sample preparation.
• Data collection.
• Data processing.
• Structure solving.

Education, Experience and Skills:

• PhD with 1+yrs of postdoctoral and/or industry experience in Structural Biology, Biophysics, Protein Biochemistry or related discipline.
• Strong experience in cryo-EM and x-ray crystallography is required.
• The ideal candidate should be detail-oriented, organized and demonstrate good lab practices.
• Must be a collaborative team player with strong communication skills.
• Have excellent communication skills.
• Should be able to clearly articulate data, project strategies both internally and externally.
• Experience in biophysical characterization (SPR, DSF, MST etc.) is a plus.