Scientist – II

Job Description

• Job Summary:
  We are seeking an exceptional Scientist in the Boston Discovery Biologics group, with the primary responsibility to execute cell-based binding and functional assays.
• The qualified candidate will be a scientist with core capabilities in cell culture, automation and high-throughput cell-based assay execution and statistical data analysis in the quest to Client innovative large molecule therapeutics.
• They should have deep expertise in cell technologies, dose-response relationship and using proper statistical tools for data analysis and interpretation.
• The ideal candidate will have first-hand knowledge of aseptic technique in cell culture including subculturing and cryopreservation of cells, flow cytometry sample preparation, reporter gene assay configuration, data acquisition, analysis, and reporting.

Duties and Responsibilities:

• Contribute to the binding and functional characterization of therapeutic molecules via cellular and/or biochemical assays.
• Implement assay automation to screen drug candidates in early discovery pipelines.
• Plan, design, execute and troubleshoot in vitro pharmacological experiments to support and advance drug discovery programs.
• Maintain timely, accurate laboratory records of activities & comply with good documentation practices.
• Effectively collaborate with integrated teams in a matrix organization setting to facilitate the conduct of studies and to the success of discovery programs.

Education and Experience:

• M.S. in pharmacology, immunology, biotechnology or biology, with 1+ years or B.S. with 3+ years of relevant in vitro, cell-based assay experience, preferably in a pharmaceutical/ biotechnology setting.
• Highly relevant lab experience through degree program can be considered.
• Experience in assay development in a wide range of cellular and biochemical assays such as reporter gene assays, Ab internalization assay, enzymatic activity assays, etc.
• Experience with developing high throughput methods into workflows (e.g. Hamilton and/or Agilent Bravo automated liquid handling platform, client Momentum workflow scheduling software, etc.)
• Experience working with T cell engagers.
• Hands-on experience with mammalian cell culture, flow cytometry and related data analysis.

Knowledge, Skills and Abilities:

• Excellent communication and collaboration skills.
• ELISA and other immunological assay skills are desired.
• Working knowledge using standard data analysis tools such as Flow Jo, Graph Pad Prism and Microsoft programs.
• Familiarity with automated liquid handling systems, robotics, and high-throughput cell-based assays screening formats.
• Ability to multi-task with highly analytical mind, attention to details, and organizational skills are critical.
• Excellent written and interpersonal communication skills and the ability to collate the results and make a presentation to the stakeholders.
• The ability to work independently, as well as collaboratively with peers within and across departments is expected.
• Champion for diverse and inclusive culture.