Scientist

Job Description

Duties and Responsibilities:

• 30% – Operating LC-MS systems to perform in-process and final QC of various scales of highly modified OligonucleoProduct, including siRNA and ASO, to support both discovery portfolio and pre-portfolio projects
• 20% – Optimize methods and improve analytical capabilities for Client OligonucleoProduct synthesis
• 10% – Analyze and optimize methods in a project-specific way (i.e. GalNAc vs Cholesterol vs C16) by denaturing and non-denaturing HPLC methods. In addition, phosphonamidites or lipids by HPLC and LCMS.
• 20% – Establish and automate high throughput analytical capabilities and coordinate those efforts with higher synthesis throughput.
• 5% – Analyze OligonucleoProduct by HPLC-SEC, RP-IP and Ion-Exchange Chromatography.
• Continue optimizing siRNAs using best-in class analytical chemistry methodologies such as different column matrixes for optimal siRNA characterization.
• Support integrity confirmation requests (such as concentration) by assay development and biology teams.
• 3% – Conduct QC for lipid nanoparticle (LNP) formulations of mRNA.
• 5% – Ensure the supply of laboratory consumables and reagents are in stock as needed.
• Maintain a high level of productivity in the laboratory setting.
• 2% – Present data and reports on project status at individual, group, and departmental meetings.

Education and Experience:

• Ph.D.. with 1-3 years of experience, performing progressively advanced duties at the Scientist level, or the equivalent training/experience is required.
• Prior experience in the characterization of OligonucleoProduct and/or nucleoside/nucleo Product analytes is required.
• PhD is required.
• Must have experience with Analytical Chemistry.
• Must have experience with Oligonucleotides.
• Must have siRNA experience.
• Previous gene therapy experience.
• Must have 1-3 years of experience.
• Experience with Chromatography (LC-MS).
• Experience with these instruments:  LTQ, LC/MS or Orbitrap LC/MS

Top Three Skills:

• Operate LC-MS systems.
• Analyze and optimize methods.
• Establish and automate high throughout analytical capabilities.