Associate Scientist – Automation

Job Description

Job Summary:

• Actively seeking a highly skilled automation specialist with a strong background in liquid handling robotics and integration with supporting instrumentation.
• The ideal candidate will demonstrate innovative approaches when designing, optimizing, and implementing Next-Generation Sequencing (NGS) or cell- and organoid-based workflows on automated robotic systems.
• As part of this role, the candidate will cultivate a growth mindset and develop expertise in emerging automation technologies.
• The candidate will also conduct experiments, including scale-down, high-throughput, and automation, to enhance our team’s screening capabilities in patient-derived organoid model systems for early drug target discovery.
• This role offers a unique opportunity for the successful candidate to collaborate with diverse cross-functional scientific teams and contribute to ground breaking drug discoveries that directly impact patient health.

Responsibilities:

• Integrate Liquid Handling Robotics: Seamlessly incorporate liquid handling robotics with supporting instrumentation to execute molecular and cellular biology and organoid workflows.
• Automate Standardized Assays: Validate and deploy automated workflows for various standardized assays, including DNA/RNA purification, NGS library preparation, qPCR, cell and organoid passaging, cell/organoid media changes, cell-based viability assays, high-content cell imaging, and sample normalization.
• Collaborate and Translate Benchtop Processes: Work closely with scientists to translate benchtop processes into fully automated workflows.
• This involves programming/scripting stepwise protocols and rigorously validating processes through dry and wet runs.
• Design User-Friendly Processes: Develop and validate end-to-end processes on integrated lab automation platforms, prioritizing user-friendly design, robust execution, and secure data management.
• Troubleshoot and Enhance Efficiency: Perform advanced experimental troubleshooting alongside scientists to improve ease-of-use, process efficiency, and scientific integrity.
• Cross-Functional Collaboration: Collaborate with cross-functional teams to integrate NGS and organoid workflows into automated liquid handling systems, ensuring project success.
• Technical Troubleshooting: Address technical and instrument issues related to automation, NGS, and cell-based workflows.
• User Training: Train end-users in automated platform usage and workflow execution.
• Stay Current with Technology: Keep up-to-date with advancements in automation technology and emerging methodologies applicable to liquid handling systems.
• Independent Workflow Development: Work independently on Client automated workflows.
• Meticulous Record Keeping: Generate, organize, and maintain meticulous records of all conducted experiments.
• Collaboration and Organization: Collaborate with multiple teams across the organization, supporting and sharing methodologies while aligning efforts and harmonizing experimentation.
• Lab and Equipment Management: Manage lab and equipment organization and maintenance

Qualifications, Skills/Knowledge:

• Master’s degree with 1+ year or Bachelor’s degree with 3+ years’ experience in bioengineering or biology with a strong focus on automation platforms & liquid handlers in pharmaceutical, biotechnology companies, or academic/not-for-profit organizations.
• Minimum 3 years of hands-on experience programming and troubleshooting liquid handling platforms for high-throughput screening (HTS), as well as NGS- and organoid- or cell-based workflows.
• Direct experience with laboratory operations and maintenance of common automation instruments used for NGS workflows.
• Strong understanding of molecular and cellular biology, including NGS assays (e.g., DNA-seq, RNA-Seq).

Demonstrated utilization of these assays in practical settings:

• Proven ability to create, follow, and maintain Installation Qualifications (IQ), Operational. Qualifications (OQ), Performance Qualifications (PQ) protocols as well as Standard Operating Procedures (SOPs) for lab automation systems.
• Successfully worked with R&D teams to deliver automation projects.
• Effective communication and collaboration skills within a multidisciplinary team environment.
• Functional knowledge of at least one high-level programming language (e.g., Python).
• Additional knowledge in other programming languages (e.g., Perl, R, C++) is a plus
• Experience programming, executing, and troubleshooting workflows using client.

Dynamic Devices liquid handling platforms:

• Proficient at organizing multiple concurrent projects and tasks.
• Excellent troubleshooting and problem-solving skills.
• Rigorous and constant evaluation of own work to maintain high quality.

Preferred Skills:

• Extensive hands-on experience with high-throughput methods, liquid handlers, and laboratory automation schedulers.
• Proficiency in integrating liquid handling systems with supporting instrumentation.
• In-depth expertise of end-to-end NGS workflows, with a focus on instrumentation and automation.
• Functional understanding of cellular biology, molecular biology, DNA/RNA purification.
• Proficiency in Next-Generation Sequencing (NGS) protocols.
• Knowledge of automation programming and/or scripting (e.g., Python) for liquid handlers.
• Previous experience in manual or automated organoid culture and assay development, is a plus.

Additional Job Requirements:

• Lab w/ blood & animal.
• Position Handles Hazardous Materials.