High Throughput Purification Specialist

Job Description

Job Summary:

• We are hiring a High Throughput Purification Specialist on a contract basis for our Boston R&D Hub in Cambridge, MA.
• This role will support a team of medicinal chemists working on pep Product drug discovery programs.
• Primary responsibilities include the purification, quality control, and registration of pep Product libraries and singleton samples prior to submission for biological assays.
• The ideal candidate will have experience with high throughput, mass directed preparative Waters HPLC systems and analytical UPLC instrumentation in an industrial environment.
• Familiarity with Client instruments and Biotage Extrahera is considered a plus.

Duties and Responsibilities:

• Work closely with medicinal chemists to manage sample queues and prioritize purification requests across multiple projects.
• Execute purification of diverse pep Product libraries using optimized conditions to deliver high purity products with rapid turnaround times.
• Maintain chromatograms, spectra, purity analyses, and associated records throughout the workflow—from crude materials to final samples—for ELN documentation.
• Perform routine maintenance and basic troubleshooting of the high throughput purification platform, as well as open access preparative and analytical UPLC instruments used by medicinal chemists.
• Maintain a safe working environment and adhere to good laboratory practices.

Qualifications:

• B.S. or M.S. in Chemistry, Analytical Chemistry, or a closely related discipline.
• Strong understanding of fundamental principles of chromatography and mass spectrometry.
• 1–2 years of experience with high throughput purification workflows and automated purification systems supporting drug discovery or medicinal chemistry efforts.
• Demonstrated ability to troubleshoot instrumentation and analytical issues.
• Excellent communication skills and a collaborative, team-oriented mindset.