Scientist III

Job Description

Job Summary:

The Downstream Process Development, MSAT department supports several projects including:

• Seasonal strain changes for Flublok/Covid Vaccine.
• Process improvement and optimization projects.
• Yield improvement strategies and implementation.
• Process monitoring and control.
• Manufacturing support for production operations.

Duties and Responsibilities:

• Primary responsibilities are the execution of development studies such as resin reuse, process improvements, optimization, scale-up, column load, and evaluation of yield improvement strategies as outlined by the Deputy Director DSP/MSAT in collaboration with others on projects.
• Executes purification experiments including automated or high-throughput chromatography (AKTA platform), filtration, clarification/ depth filtration, column packing, and tangential flow filtration independently based on expert knowledge of protein purification and analysis with an in-depth understanding of all modes of chromatography.
• Makes detailed observations, analyzes data, and interprets results.
• Exercise technical discretion in the design, execution, and interpretation of experiments that contribute to projects.
• Prepares technical reports, summaries, protocols, and quantitative analyses.
• Responsible for training on, understanding, and following documented procedures that apply to their departments.
• Responsible for general lab maintenance.
• Proactively anticipates and effectively communicates successes, constraints, solutions, and actions for resolution.
• Fosters relationships with partners, experts from other functions, and customers to achieve technical objectives.
• Perform troubleshooting as required, and supports staff.
• Demonstrate and promote company values and competencies through daily actions and decisions.
• Contribute to strategic planning for downstream process development initiatives.

Education and Experience:

• Bachelor’s or Master’s in Biology, Biomedical, Biotechnology, Biochemistry, or similar discipline.
• 2 – 6 Years of Experience.

Core Competencies:

• Fluent in English (written and verbal communication).
• Good communication and interpersonal skills.
• Excellent team member spirit.
• Proficiency in Microsoft Office Suite including Word, Excel, PowerPoint).

Preferred Qualifications:

• Operating, maintaining, and troubleshooting chromatography workstations and process skids.
• Analyzing Data with Assay (SDS PAGE and Western Blot, SRID, BCA, Purity, Dialysis for rBV, ELISA, etc.)
• Knowledge and experience working with automated high throughput process development equipment.
• Demonstrates working knowledge of scientific principles and concerns.
• Participates in quality control tracking systems including change controls, deviations, CAPA, root cause analysis, etc.
• Maintains project timelines.
• Good documentation practices (GDP). Experience in writing standard operating procedures (SOP), batch records, and reports.
• Hands-on experience with molecular modeling software is desirable but not required.